Amanda Randles

Amanda has established an ambitious research program focused around the transformation of her circulatory modeling code HARVEY into a world-class research tool capable of making a direct clinical impact. HARVEY is a massively parallel circulatory simulation code capable of modeling the full human arterial system at subcellular resolution. Her work leverages high performance computing to solve biomedical problems. She has developed large-scale computational methods to study disease localization and progression to foster discoveries that will serve as a basis for improving the diagnosis, prevention, and treatment of human diseases.

Together with an interdisciplinary team of doctors, scientists, and computer scientists Amanda has developed several new methods of high-performance computer simulations for blood flow in arteries across multiple scales  from molecules to blood cells. She has been applying theories from cosmology to the simulation of the forces from the beating heart. She developed her own parallel application code (HARVEY) to model flow in microfluidic devices and aneurysms as well as in coronary arteries. Amanda's multi-disciplinary background in applied physics and of computational methods and parallelization strategies in computer science, serves her well in these endeavors.

Amanda has remained keenly aware of the need to translate computational results into actionable data doctors can use to improve patient outcomes, and has continued to build collaborations that will allow her use this new computational capability to bridge the gap from the computer to the clinic. Her cross-disciplinary approach will yield new insights into efficient fluid flow simulations for complex multi-scale systems that will be useful well beyond blood flow simulations.